A multicentre, prospective, randomized trial: comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy for distal ureteric stones with renal colic.

Abstract

OBJECTIVE:

• To determine the comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy (MET) for distal ureteric stones with renal colic.

PATIENTS AND METHODS:

• We evaluated the comparative efficacy of tamsulosin and nifedipine in MET in a prospective randomized trial of 3189 outpatients from 10 centres in China. • Eligible patients randomly received tamsulosin or nifedipine. Efficacies of the two agents in MET were compared at 4 weeks. • The primary endpoint was overall stone-expulsion rate. • Secondary endpoints were stone-expulsion time, rate of pain relief therapy, mean analgesic consumption for renal colic recurrence, and side-effects incidence.

RESULTS:

• Stone-expulsion rates in the tamsulosin group (group 1) were greater than those in the nifedipine group (group 2; P < 0.01). • There was a significant variation in stone-expulsion rates and times between groups 1 and 2 (P < 0.01); with improvements in stone-expulsion rate and time significantly better in group 1 than in group 2. • There was a significant variation in the rate of pain relief therapy for renal colic recurrence between groups 1 and 2 (P < 0.01); patients in group 1 required significantly less analgesics than those in group 2 (P < 0.01). • There were no statistically significant differences in side-effects incidence between the groups.

CONCLUSIONS:

• Administration of tamsulosin and nifedipine in MET was determined to be safe and effective for distal ureteric stones with renal colic. • Tamsulosin was significantly better than nifedipine in relieving renal colic and facilitating ureteric stone expulsion.

• Authors: Zhangqun Ye, Huan Yang, Hong Li, Xiaochun Zhang, Yaoliang Deng, Guohua Zeng, Lingwu Chen, Yue Cheng, Jianggen Yang, Qiwu Mi, Yonghai Zhang, Zhong Chen, Hui Guo, Wei He, Zhiqiang Chen
• Journal: BJU international (BJU Int) Vol. 108 Issue 2 Pg. 276-9 (Jul 2011) ISSN: 1464-410X [Electronic] England
• PMID: 21083640 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2010 THE AUTHORS. BJU INTERNATIONAL © 2010 BJU INTERNATIONAL.

Chemical References

• Adrenergic alpha-1 Receptor Antagonists
• Sulfonamides
• Tamsulosin
• Nifedipine

Topics

• Adolescent
• Adrenergic alpha-1 Receptor Antagonists (therapeutic use)
• Adult
• China
• Epidemiologic Methods
• Female
• Humans
• Male
• Middle Aged
• Nifedipine (therapeutic use)
• Renal Colic (drug therapy, etiology)
• Sulfonamides (therapeutic use)
• Tamsulosin
• Treatment Outcome
• Ureteral Calculi (complications, drug therapy)
• Young Adult