Abstract | BACKGROUND:
Epidermolysis bullosa acquisita (EBA) is a rare, chronic, autoimmune bullous dermatosis that is caused by autoantibodies against the noncollagenous terminus of the α chain of type VII collagen, resulting in decreased anchoring fibrils in the lamina densa. It classically presents with skin fragility and trauma-induced blisters that are particularly extensive over the distal aspect of the extremities and that heal with milia, dyspigmentation, and scarring, similar in presentation to dystrophic epidermolysis bullosa. Disease onset is typically in adulthood, although rare cases of childhood disease occur. To our knowledge, a case involving a neonate with congenital EBA has not yet been reported in the literature. We describe a newborn with transient EBA due to the passive transfer of maternal autoantibodies. OBSERVATIONS: A 2-day-old girl was evaluated for tense blisters and areas of denuded skin that had been present since birth. Her mother carried the diagnosis of EBA. The results of histopathologic analysis, immunofluorescence studies, and enzyme-linked immunosorbent assay confirmed the diagnosis of neonatal EBA. The patient improved with supportive therapy and has not required systemic intervention. CONCLUSIONS:
|
Authors | Melissa L Abrams, Aimee Smidt, Latanya Benjamin, Mei Chen, David Woodley, Anthony J Mancini |
Journal | Archives of dermatology
(Arch Dermatol)
Vol. 147
Issue 3
Pg. 337-41
(Mar 2011)
ISSN: 1538-3652 [Electronic] United States |
PMID | 21079052
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
|
Topics |
- Adult
- Autoantibodies
(immunology)
- Enzyme-Linked Immunosorbent Assay
- Epidermolysis Bullosa Acquisita
(diagnosis, immunology, pathology)
- Female
- Fluorescent Antibody Technique
- Humans
- Immunization, Passive
- Infant, Newborn
- Placenta
(metabolism)
- Pregnancy
|