The present study was undertaken to determine the anti-
ulcer and
antioxidant potential of
GutGard, a standardized extract of Glycyrrhiza glabra commonly known as licorice. Effect of various doses (12.5, 25, and 50 mg/kg, po) of
GutGard was studied on
gastric ulcers in pylorus
ligation-, cold-restraint stress- and
indomethacin induced gastric mucosal injury in rats. Anti-
ulcer activity was evaluated by measuring the
ulcer index, gastric content, total acidity, and pH of gastric fluid.
GutGard dose dependently decreased gastric content, total acidity,
ulcer index and increased pH of gastric fluid in pylorus
ligation ulcer model. In cold-restraint stress- and
indomethacin induced
ulcer models all the doses of
GutGard decreased the
ulcer index and increased the pH of gastric fluid. The
antioxidant activity was evaluated by the
oxygen radical absorbance capacity (ORAC) assay. GutGardT exhibited potent
antioxidant activity with high hydrophilic and lipophilic ORAC value.
GutGard possessed anti-ulcerogenic properties that might be afforded via cytoprotective mechanism by virtue of its
antioxidant properties. These results supported the ethnomedical uses of licorice in the treatment of
gastric ulcer.