[An analysis of efficacy and related factors of itraconazole in the treatment of invasive fungal infection in hematological diseases].

Abstract

OBJECTIVE:

To investigate the effects and related factors of itraconazole in the treatment of invasive fungal infection (IFI) in the patients with blood diseases (BD).

METHODS:

A total of 156 BD patients with IFI treated with itraconazole in General Hospital, Tianjin Medical University from 2005 to 2008, were retrospectively analyzed.

RESULTS:

Of these patients, 92 were with underlying malignant BD, and 64 with non-malignant BD; 77 possible IFI, and others proven IFI. A total of 94 (63.5%) patients were responded to itraconazole successfully, while 54 (36.5%) failed. The underlying malignant BD, post-chemotherapy, neutrophil count less than 0.5×10(9)/L, positive fungus culture, and bacteria infection were related with the response to itraconazole significantly, while patient's age, application of other antibiotics, positive G test, IFI localization, haemoglobin level and platelet counts were not. Five patients was changed other anti-IFI therapy because of side effects, including gastrointestinal ill (3 cases with nausea or vomiting) and tachycardia (2 cases).

CONCLUSIONS:

Itraconazole was effective and safe in the treatment of IFI in the patients with BD. Underlying malignant BD, agranulocytosis, bacteria infection, and delayed anti-IFI therapy might reduce itraconazole therapeutic effects.

• Authors: Chun-yan Liu, Rong Fu, Yu-hong Wu, Er-bao Ruan, Wen Qu, Guo-jin Wang, Yong Liang, Xiao-ming Wang, Hong Liu, Jia Song, Jing Guan, Hua-quan Wang, Li-min Xing, Li-juan Li, Jun Wang, Zong-hong Shao
• Journal: Zhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 49 Issue 6 Pg. 504-7 (Jun 2010) ISSN: 0578-1426 [Print] China
• PMID: 20979739 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents
• Itraconazole

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Antifungal Agents (therapeutic use)
• Child
• Female
• Hematologic Diseases (microbiology)
• Humans
• Itraconazole (therapeutic use)
• Male
• Middle Aged
• Mycoses (drug therapy)
• Retrospective Studies
• Young Adult