Abstract | AIM OF THE STUDY: MATERIALS AND METHODS: Thirty two Wistar rats were divided into 4 groups, with 8 rats in each group. The first group was sham operated ( Sham), the second group was ovariectomised (OVX), the third (LPva) and fourth group (ERT) were also ovariectomised and given LPva 17.5 mg/kg and Premarin(®) 64.5 μg/kg, respectively. Blood samples were taken before and after treatment to measure osteocalcin and C-terminal telopeptide of type 1 collagen levels using ELISA while the fifth lumbar bone samples were taken to measure bone calcium content using the Atomic Absorption Spectrophotometer (AAS). RESULTS: The osteocalcin levels were significantly higher in both the LPva and ERT groups compared to the OVX group. The CTX levels were significantly lower in both the LPva and ERT groups compared to the OVX group. However, only the ERT group had significantly higher bone calcium level compared to the OVX group. CONCLUSION: The supplementation of 17.5 mg/kg of LPva to ovariectomised rats for 8 weeks was able to prevent the changes in bone biochemical markers but failed to prevent the bone calcium loss induced by ovariectomy.
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Authors | Ahmad Nazrun Shuid, Leong Lee Ping, Norliza Muhammad, Norazlina Mohamed, Ima Nirwana Soelaiman |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 133
Issue 2
Pg. 538-42
(Jan 27 2011)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 20971181
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Biomarkers
- Plant Extracts
- Calcium
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Topics |
- Animals
- Biomarkers
(metabolism)
- Bone and Bones
(drug effects, metabolism)
- Calcium
(metabolism)
- Disease Models, Animal
- Ethnopharmacology
- Female
- Humans
- Malaysia
- Medicine, East Asian Traditional
- Osteoporosis, Postmenopausal
(drug therapy, metabolism)
- Phytotherapy
- Plant Extracts
(pharmacology)
- Plants, Medicinal
(chemistry)
- Primulaceae
(chemistry)
- Rats
- Rats, Wistar
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