Abstract | OBJECTIVE: METHODS: The experiment was conducted in the Laboratory, Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China from June 2009 to December 2009. In this study, the rat model of NASH was produced by feeding high-fat diet. Sixty rats were randomly divided into 3 groups: Normal group: normal diet, drinking water; Model group: high-fat diet, single-distilled water 10 ml/kg gavage once a day for 12 weeks; and Treated group: high-fat diet, EGB 6 mg/kg gavage once a day for 12 weeks. At the end of 12 weeks, all rats were killed. The serum biochemical, fibrosis markers, superoxide dismutase (SOD), malondialdehyde (MDA), the pathological changes, and the expression levels of nuclear factor KB (NF-κB)p65 protein in the liver were observed. RESULTS: CONCLUSION:
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Authors | Zhong-Yin Zhou, Shi-Qi Tang, Yong-Ming Zhou, He-Sheng Luo, Xing Liu |
Journal | Saudi medical journal
(Saudi Med J)
Vol. 31
Issue 10
Pg. 1114-8
(Oct 2010)
ISSN: 0379-5284 [Print] Saudi Arabia |
PMID | 20953526
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- Plant Extracts
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Topics |
- Animals
- Antioxidants
(pharmacology)
- Fatty Liver
(prevention & control)
- Ginkgo biloba
(chemistry)
- Liver
(drug effects)
- Plant Extracts
(pharmacology)
- Rats
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