Abstract | BACKGROUND: METHODS: RESULTS: Of 200 consecutive breast cancer patients, 191 received the full package. During the first 36 postoperative hours, 79.1% reported no PONV at all and only 3.7% reported severe PONV. At rest, 69.6% reported no or light pain and 3.1% reported severe pain, with corresponding values of 59.7% and 8.9% during arm mobilization. Mean postoperative morphine consumption was 2.2 mg. The only significant side effect was transient dizziness. CONCLUSION: A multimodal, opiate-sparing regimen to prevent pain and PONV seems to be more effective than one- or two-component regimens on PONV and pain after breast cancer surgery, a result which calls for large-scale multi-center or randomized studies.
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Authors | R Gärtner, N Kroman, T Callesen, H Kehlet |
Journal | Minerva anestesiologica
(Minerva Anestesiol)
Vol. 76
Issue 10
Pg. 805-13
(Oct 2010)
ISSN: 1827-1596 [Electronic] Italy |
PMID | 20935616
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Amines
- Analgesics, Non-Narcotic
- Antiemetics
- Cyclohexanecarboxylic Acids
- Narcotics
- Pyrazoles
- Sulfonamides
- Acetaminophen
- Ondansetron
- gamma-Aminobutyric Acid
- Gabapentin
- Dextromethorphan
- Morphine
- Dexamethasone
- Celecoxib
- Fentanyl
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Topics |
- Acetaminophen
(administration & dosage, adverse effects, therapeutic use)
- Aged
- Amines
(administration & dosage, adverse effects, therapeutic use)
- Analgesics, Non-Narcotic
(administration & dosage, adverse effects, therapeutic use)
- Anesthesia Recovery Period
- Anesthesia, Intravenous
- Antiemetics
(administration & dosage, adverse effects, therapeutic use)
- Breast Neoplasms
(surgery)
- Celecoxib
- Combined Modality Therapy
- Cyclohexanecarboxylic Acids
(administration & dosage, adverse effects, therapeutic use)
- Dexamethasone
(administration & dosage, adverse effects, therapeutic use)
- Dextromethorphan
(administration & dosage, adverse effects, therapeutic use)
- Female
- Fentanyl
- Gabapentin
- Humans
- Intraoperative Care
- Lymph Node Excision
- Mastectomy
- Middle Aged
- Morphine
(adverse effects, therapeutic use)
- Narcotics
(adverse effects, therapeutic use)
- Nervous System Diseases
(chemically induced)
- Ondansetron
(administration & dosage, adverse effects, therapeutic use)
- Pain, Postoperative
(etiology, prevention & control)
- Pilot Projects
- Postoperative Nausea and Vomiting
(etiology, prevention & control)
- Preanesthetic Medication
- Pyrazoles
(administration & dosage, adverse effects, therapeutic use)
- Sentinel Lymph Node Biopsy
- Sulfonamides
(administration & dosage, adverse effects, therapeutic use)
- gamma-Aminobutyric Acid
(administration & dosage, adverse effects, therapeutic use)
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