Histone demethylases in development and disease.

Abstract

Histone modifications serve as regulatory marks that are instrumental for the control of transcription and chromatin architecture. Strict regulation of gene expression patterns is crucial during development and differentiation, where diverse cell types evolve from common predecessors. Since the first histone lysine demethylase was discovered in 2004, a number of demethylases have been identified and implicated in the control of gene expression programmes and cell fate decisions. Histone demethylases are now emerging as important players in developmental processes and have been linked to human diseases such as neurological disorders and cancer.

• Authors: Marianne Terndrup Pedersen, Kristian Helin
• Journal: Trends in cell biology (Trends Cell Biol) Vol. 20 Issue 11 Pg. 662-71 (Nov 2010) ISSN: 1879-3088 [Electronic] England
• PMID: 20863703 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Histone Demethylases

Topics

• Animals
• Gene Expression Regulation
• Histone Demethylases (genetics, metabolism)
• Humans
• Mammals (growth & development, metabolism)
• Neoplasms (drug therapy, metabolism)
• Nervous System Diseases (drug therapy, metabolism)