[Expression of pituitary tumor transforming gene in human renal clear cell carcinoma and its significance].

Abstract

OBJECTIVE:

To explore the expression of pituitary tumor transforming gene (PTTG) in human renal clear cell carcinoma (RCCC) and its significance.

METHODS:

PTTG protein expression was detected by immunohistochemistry in 87 RCCC and 45 paired normal renal tissues.

RESULTS:

PTTG was expressed differentially between the normal renal and RCCC tissues. Compared with normal tissues, the primary RCCC tissues showed significantly increased expression of PTTG protein (P<0.001). The positive rate of PTTG protein was positively correlated to the tumor size, clinical stage and Fuhrman grade of RCCC (P=0.009, 0.008 and 0.035, respectively).

CONCLUSION:

Increased PTTG protein expression may be involved in the carcinogenesis and progression of RCCC.

• Authors: Ming-hua Tang, Jian Tan, Fei-lun Cui
• Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 30 Issue 7 Pg. 1712-4 (Jul 2010) ISSN: 1673-4254 [Print] China
• PMID: 20650808 (Publication Type: English Abstract, Journal Article)

Chemical References

• Neoplasm Proteins
• Securin
• pituitary tumor-transforming protein 1, human

Topics

• Adult
• Aged
• Carcinoma, Renal Cell (metabolism, pathology)
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Immunohistochemistry
• Kidney Neoplasms (metabolism, pathology)
• Male
• Middle Aged
• Neoplasm Proteins (genetics, metabolism)
• Securin