Serotonin 1A receptor gene, schizophrenia and bipolar disorder: an association study and meta-analysis.

Abstract

Several investigations have reported associations between serotonin 1A (5-HT1A) receptor and major psychiatric disorders, such as schizophrenia and bipolar disorder (BP), making the 5-HT1A receptor gene (HTR1A) a good candidate gene for the pathophysiology of schizophrenia and BP. To evaluate the association between HTR1A and schizophrenia and BP, we conducted a case-control study of Japanese population samples with two single- nucleotide polymorphisms (SNPs), including rs6295 (C-1019G) in HTR1A. In addition, we conducted a meta-analysis of rs6295, which has been examined in other studies. Using one functional single- nucleotide polymorphism (SNP; rs6295) and one tagging SNP (rs878567), we conducted a genetic association analysis of case-control samples (857 schizophrenic patients, 1028 BP patients and 1810 controls) in the Japanese population. Two association studies for schizophrenia and three association studies for BP, including this study, met our criteria for the meta-analysis of rs6295. We found an association between HTR1A and Japanese BP in a haplotype-wise analysis, the significance of which remained after Bonferroni correction. In addition, we detected an association between rs6295 and BP in the meta-analysis (fixed model: P(Z)=0.000400). However, we did not detect an association between HTR1A and schizophrenia in the allele/genotype-wise, haplotype-wise or meta-analysis. HTR1A may play an important role in the pathophysiology of BP, but not schizophrenia in the Japanese population. In the meta-analysis, rs6295 in HTR1A was associated with BP patients.

• Authors: Taro Kishi, Tomo Okochi, Tomoko Tsunoka, Takenori Okumura, Tsuyoshi Kitajima, Kunihiro Kawashima, Yoshio Yamanouchi, Yoko Kinoshita, Hiroshi Naitoh, Toshiya Inada, Hiroshi Kunugi, Tadafumi Kato, Takeo Yoshikawa, Hiroshi Ujike, Norio Ozaki, Nakao Iwata
• Journal: Psychiatry research (Psychiatry Res) Vol. 185 Issue 1-2 Pg. 20-6 (Jan 30 2011) ISSN: 0165-1781 [Print] Ireland
• PMID: 20594600 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Crown Copyright © 2010. Published by Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Receptor, Serotonin, 5-HT1A

Topics

• Asian People
• Bipolar Disorder (genetics)
• Case-Control Studies
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Genome-Wide Association Study (methods)
• Genotype
• Humans
• Linkage Disequilibrium
• Logistic Models
• Male
• Meta-Analysis as Topic
• Polymorphism, Single Nucleotide (genetics)
• Receptor, Serotonin, 5-HT1A (genetics)
• Schizophrenia (genetics)