Abstract | BACKGROUND AND AIM: METHODS: RESULTS: In rats with acute liver failure, GM treatment significantly decreased the plasma levels of alanine aminotransferase (P = 0.02), but no significant difference of motor activity, plasma levels of ammonia, IL-1beta, IL-6, IL-10 and TNF-alpha or survival was found. In chronic liver failure rats, GM significantly lowered the plasma TNF-alpha levels (P = 0.04). However, there was no significant difference of motor activity, other biochemical tests or survival found. GM-treated chronic liver failure rats had higher portal pressure (P = 0.04) but similar mean arterial pressure in comparison with saline-treated rats. CONCLUSIONS:
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Authors | Chia-Yang Hsu, Fa-Yauh Lee, Teh-Ia Huo, Cho-Yu Chan, Hui-Chun Huang, Han-Chih Lin, Ching-Chih Chang, Tzu-Hua Teng, Sun-Sang Wang, Shou-Dong Lee |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 25
Issue 7
Pg. 1321-8
(Jul 2010)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 20594263
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Biomarkers
- Enzymes
- Inflammation Mediators
- Serine Proteinase Inhibitors
- Thioacetamide
- Gabexate
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Biomarkers
(blood)
- Blood Pressure
(drug effects)
- Chronic Disease
- Common Bile Duct
(surgery)
- Disease Models, Animal
- Enzymes
(blood)
- Gabexate
(pharmacology)
- Hepatic Encephalopathy
(blood, etiology, physiopathology, prevention & control)
- Inflammation Mediators
(blood)
- Ligation
- Liver
(blood supply, drug effects, metabolism)
- Liver Failure
(blood, drug therapy, etiology, physiopathology)
- Liver Failure, Acute
(blood, chemically induced, drug therapy, physiopathology)
- Male
- Motor Activity
(drug effects)
- Portal Pressure
(drug effects)
- Rats
- Rats, Sprague-Dawley
- Serine Proteinase Inhibitors
(pharmacology)
- Severity of Illness Index
- Thioacetamide
- Time Factors
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