Abstract |
Hippuristanol is a natural product that has recently been shown to inhibit eukaryotic translation initiation and tumor cell proliferation. To investigate the structure and activity relationship of hippuristanol, we synthesized a series of analogs by expanding the size of its F ring and determined their effects on the proliferation of cancer cell lines. All changes to the F-ring of hippuristanol resulted in 3-fold to >100-fold decrease in activity.
|
Authors | Wei Li, Yongjun Dang, Jun O Liu, Biao Yu |
Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 20
Issue 10
Pg. 3112-5
(May 15 2010)
ISSN: 1464-3405 [Electronic] England |
PMID | 20409710
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright 2010 Elsevier Ltd. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Furans
- Spiro Compounds
- Sterols
- hippuristanol
- spiroketal
|
Topics |
- Antineoplastic Agents
(chemical synthesis, chemistry, pharmacology)
- Furans
(chemistry)
- HeLa Cells
- Humans
- Spiro Compounds
(chemistry)
- Stereoisomerism
- Sterols
(chemical synthesis, chemistry, pharmacology)
- Structure-Activity Relationship
|