Induction concurrent chemoradiotherapy compared with induction radiotherapy for superior sulcus non-small cell lung cancer: a retrospective study.

Abstract

AIM:

To evaluate the efficacy of current chemoradiotherapy on improvement of survival in patients with superior sulcus non-small cell lung cancer (NSCLC).

METHODS:

We retrospectively reviewed the data of 39 patients with superior sulcus NSCLC treated with induction therapy followed surgery. The patients were divided into two groups according to the induction approach: the induction radiotherapy (RT) group (1993-1999), and the induction chemoradiotherapy (CT/RT) group (since 1999).

RESULTS:

The rate of complete resection was 65 percent in the RT group (n = 17) compared with 91 percent in the CT/RT group (n = 22, P = 0.024). Complete pathological responses from induction therapy were 12 percent in the RT group and 45 percent in the CT/RT group (P = 0.032). Overall survival (OS) was significantly longer in patients who received CT/RT than that in those who received RT, with 2- and 5-year survival rates of 77.3 percent and 36.4 percent versus 41.2 percent and 11.8 percent, respectively (P = 0.007). CT/RT also associated with a markedly longer tumor-free survival (TFS), with a median TFS of 40 and 17 months, respectively (P = 0.007). Patients achieved complete resection or complete pathological response had a significantly better survival than those with incomplete resection or pathological partial responses and no change (P < 0.0005 and P = 0.001, respectively).

CONCLUSION:

Our results indicate that CT/RT followed by surgery can significantly improve OS and TFS, and may be considered as an optimal option in treatment of patients with superior sulcus NSCLC.

• Authors: Jian Li, Chun-Hua Dai, Shun-Bing Shi, Qian-Lei Bao, Li-Chao Yu, Jian-Rong Wu
• Journal: Asia-Pacific journal of clinical oncology (Asia Pac J Clin Oncol) Vol. 6 Issue 1 Pg. 57-65 (Mar 2010) ISSN: 1743-7563 [Electronic] Australia
• PMID: 20398039 (Publication Type: Comparative Study, Journal Article)

Topics

• Adult
• Aged
• Carcinoma, Non-Small-Cell Lung (therapy)
• Combined Modality Therapy
• Female
• Humans
• Lung Neoplasms (therapy)
• Male
• Middle Aged
• Pancoast Syndrome (therapy)
• Retrospective Studies
• Treatment Outcome