Abstract | CONTEXT: OBJECTIVE: PATIENTS AND METHODS: Eighty-three patients were included, and 29 were treated preoperatively with SMS. Adenoma E-cadherin protein expression was analyzed by Western blot (61 patients) and immunohistochemistry (IHC) (80 patients) with antibodies directed against both extracellular and intracellular domains (IHC). The acute (direct surgery group) and long-term (preoperatively treated group) SMS responses were evaluated. Baseline tumor volume and invasiveness were measured on magnetic resonance imaging scans. RESULTS: CONCLUSION:
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Authors | Stine Lyngvi Fougner, Tove Lekva, Olivera Casar Borota, John K Hald, Jens Bollerslev, Jens Petter Berg |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 95
Issue 5
Pg. 2334-42
(May 2010)
ISSN: 1945-7197 [Electronic] United States |
PMID | 20335450
(Publication Type: Journal Article)
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Chemical References |
- CTAP octapeptide
- Cadherins
- Peptide Fragments
- Somatostatin
- Insulin-Like Growth Factor I
- Growth Hormone
|
Topics |
- Acromegaly
(complications, surgery)
- Adult
- Cadherins
(genetics, metabolism)
- Female
- Growth Hormone
(blood)
- Humans
- Immunohistochemistry
- Insulin-Like Growth Factor I
(metabolism)
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Neoplasm Invasiveness
- Peptide Fragments
(therapeutic use)
- Pituitary Neoplasms
(drug therapy, genetics, pathology, surgery)
- Somatostatin
(analogs & derivatives, therapeutic use)
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