Abstract | BACKGROUND: OBJECTIVE: DESIGN: Postmenopausal women were randomly assigned to an intervention or a comparison group for a mean of 8.1 y. Lipoprotein analyses and subclasses were based on subsamples of 2730 and 209 participants, respectively. RESULTS: At year 6, the total reported fat intake was 7.8% lower and carbohydrate intake was 7.6% higher in the intervention group than in the comparison group. Triglyceride change between groups differed by 2.3, 3.8, and -0.8 mg/dL at 1, 3, and 6 y, respectively, and HDL-cholesterol change differed by -1.6, -0.7, and -1.0 mg/dL at 1, 3, and 6 y, respectively. Changes did not differ by age, ethnicity, or obesity. In diabetic intervention women who were white, the triglyceride difference between the intervention and comparison groups was 33.8 mg/dL, whereas in black women with diabetes (n = 50 in the intervention group; n = 83 in the comparison group), the triglyceride difference was 6.4 mg/dL (P for 3-factor interaction = 0.049). No significant changes were observed in apolipoprotein or lipoprotein particles. Reductions in LDL cholesterol varied by quartile of reported lowering of saturated or trans fat. CONCLUSIONS:
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Authors | Barbara V Howard, J David Curb, Charles B Eaton, Charles Kooperberg, Judith Ockene, John B Kostis, Mary Pettinger, Aleksandar Rajkovic, Jennifer G Robinson, Jacques Rossouw, Gloria Sarto, James M Shikany, Linda Van Horn |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 91
Issue 4
Pg. 860-74
(Apr 2010)
ISSN: 1938-3207 [Electronic] United States |
PMID | 20164311
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Cholesterol, HDL
- Cholesterol, LDL
- Dietary Carbohydrates
- Dietary Fats
- Fatty Acids
- Fatty Acids, Unsaturated
- Lipoproteins
- Triglycerides
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Topics |
- Black or African American
- Aged
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Diabetes Mellitus
(blood, ethnology)
- Diet, Fat-Restricted
- Dietary Carbohydrates
(administration & dosage)
- Dietary Fats
(administration & dosage)
- Fatty Acids
(administration & dosage)
- Fatty Acids, Unsaturated
(administration & dosage)
- Feeding Behavior
- Female
- Humans
- Lipoproteins
(blood)
- Middle Aged
- Postmenopause
- Risk Factors
- Triglycerides
(blood)
- United States
- White People
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