Mycobacterium marinum infection complicated by anti-tumour necrosis factor therapy.

Abstract

Mycobacteria other than tuberculosis infections in patients taking various tumour necrosis factor (TNF)-alpha inhibitors have been reported in the literature. We describe sporotrichoid spread of Mycobacterium marinum in a man with Crohn's disease treated with infliximab. After starting ethambutol and rifampicin and discontinuing infliximab, a worsening appeared. M. marinum infection may have a potential local spread and systemic dissemination in patients treated with TNF-alpha inhibitors.

• Authors: José M Ramos, Mariana F García-Sepulcre, Juan C Rodríguez, Sergio Padilla, Félix Gutiérrez
• Journal: Journal of medical microbiology (J Med Microbiol) Vol. 59 Issue Pt 5 Pg. 617-621 (May 2010) ISSN: 1473-5644 [Electronic] England
• PMID: 20133411 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antitubercular Agents
• Immunosuppressive Agents
• Tumor Necrosis Factor-alpha
• Ethambutol
• Rifampin

Topics

• Adult
• Antitubercular Agents (therapeutic use)
• Crohn Disease (complications, drug therapy)
• Ethambutol (therapeutic use)
• Humans
• Immunosuppressive Agents (adverse effects, therapeutic use)
• Male
• Mycobacterium Infections, Nontuberculous (diagnosis, microbiology)
• Mycobacterium marinum (isolation & purification)
• Rifampin (therapeutic use)
• Skin (pathology)
• Tumor Necrosis Factor-alpha (antagonists & inhibitors)