Abstract | BACKGROUND/PURPOSE: METHODS: RESULTS: A total of 133 rat fetuses with CDH were investigated. The body weight and the lung weight of fetuses of all groups that were exposed to nitrofen were significantly decreased than of the control group (P < 0.05). The animals exposed to nitrofen with different antioxidants showed increased protein levels in lung tissue. However, in the NCE and the NNAC groups, protein levels were significantly increased than in the others. Malondialdehyde levels significantly decreased in the NCE and the NNAC groups when compared with the NC and the NE groups. In addition, the NCE and NNAC groups decreased protein oxidation to control levels, and no significant difference was observed between control and these two antioxidants groups. The N, NC, NE and NNAC groups showed minimal improvement in lung histology; the NCE groups showed the most improvement in lung histology when compared with the other nitrofen plus antioxidant groups. CONCLUSION: Prenatal administration of NAC and vitamin E in combination with vitamin C represented the best effects to avoid oxidative damage and protein content of the lungs in rat pups with CDH at birth.
|
Authors | Murat Kemal Cigdem, Goksel Kizil, Abdurrahman Onen, Murat Kizil, Yusuf Nergiz, Yusuf Celik |
Journal | Pediatric surgery international
(Pediatr Surg Int)
Vol. 26
Issue 4
Pg. 401-6
(Apr 2010)
ISSN: 1437-9813 [Electronic] Germany |
PMID | 20127338
(Publication Type: Journal Article)
|
Chemical References |
- Antioxidants
- Free Radical Scavengers
- Pesticides
- Phenyl Ethers
- Proteins
- Thiobarbituric Acid Reactive Substances
- Vitamin E
- nitrofen
- Ascorbic Acid
- Acetylcysteine
|
Topics |
- Acetylcysteine
(therapeutic use)
- Animals
- Antioxidants
(therapeutic use)
- Ascorbic Acid
(therapeutic use)
- Disease Models, Animal
- Drug Synergism
- Female
- Fetus
(drug effects)
- Free Radical Scavengers
(therapeutic use)
- Hernia, Diaphragmatic
(chemically induced, complications)
- Hernias, Diaphragmatic, Congenital
- Lipid Peroxidation
(drug effects)
- Lung
(drug effects)
- Lung Diseases
(prevention & control)
- Male
- Maternal-Fetal Exchange
- Pesticides
- Phenyl Ethers
(administration & dosage)
- Pregnancy
- Proteins
(drug effects, metabolism)
- Rats
- Rats, Sprague-Dawley
- Thiobarbituric Acid Reactive Substances
(metabolism)
- Vitamin E
(therapeutic use)
|