Abstract | OBJECTIVE: METHODS: RESULTS: Expressions of collagen I, collagen III, MMP-9 and Smad-3 were significantly increased in groups A and B compared to group C (P < 0.01 or P < 0.05). Expressions of PPARalpha and RXRalpha (0.156 and 0.192, respectively, in group A; 0.248 and 0.385, respectively, in group B) were decreased compared to group C (P < 0.01 or P < 0.05). These changes were significantly attenuated by carnitine (all P < 0.05, group B vs. group A). Moreover, PPARalpha and RXRalpha positively correlated with EF and FS, and negatively correlated LVEDd, collagen I , collagen III, MMP-9 and Smad-3 (all P < 0.01). CONCLUSION:
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Authors | Ling Jing, Wei-min Li, Li-jun Zhou, Bao-feng Yang |
Journal | Zhonghua xin xue guan bing za zhi
(Zhonghua Xin Xue Guan Bing Za Zhi)
Vol. 37
Issue 4
Pg. 324-9
(Apr 2009)
ISSN: 0253-3758 [Print] China |
PMID | 19791468
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- PPAR alpha
- Retinoid X Receptor alpha
- Carnitine
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Topics |
- Animals
- Cardiomyopathy, Alcoholic
(metabolism, pathology, prevention & control)
- Carnitine
(therapeutic use)
- Male
- Myocardium
(metabolism, pathology)
- PPAR alpha
(metabolism)
- Rats
- Rats, Wistar
- Retinoid X Receptor alpha
(metabolism)
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