Contact allergy to epoxy (meth)acrylates.

Abstract

BACKGROUND:

Contact allergy to epoxy (meth)acrylates, 2,2-bis[4-(2-hydroxy-3-methacryloxypropoxy) phenyl]propane (bis-GMA), 2,2-bis[4-(2-hydroxy-3-acryloxypropoxy)phenyl]-propane (bis-GA), 2,2-bis[4-(methacryl-oxyethoxy)phenyl] propane (bis-EMA), 2,2-bis[4-(methacryloxy)phenyl]-propane (bis-MA), and glycidyl methacrylate (GMA) is often manifested together with contact allergy to diglycidyl ether of bisphenol A (DGEBA) epoxy resin.

OBJECTIVE:

To analyse patterns of concomitant allergic reactions to the five epoxy (meth)acrylates in relation to exposure.

METHODS:

We reviewed the 1994-2008 patch test files at the Finnish Institute of Occupational Health (FIOH) for reactions to the five epoxy (meth)acrylates, and examined the patients' medical records for exposure.

RESULTS:

Twenty-four patients had an allergic reaction to at least one of the studied epoxy (meth)acrylates, but specific exposure was found only in five patients: two bis-GMA allergies from dental products, two bis-GA allergies from UV-curable printing inks, and one bis-GA allergy from an anaerobic glue. Only 25% of the patients were negative to DGEBA epoxy resin.

CONCLUSIONS:

The great majority of allergic patch test reactions to bis-GMA, bis-GA, GMA and bis-EMA were not associated with specific exposure, and cross-allergy to DGEBA epoxy resin remained a probable explanation. However, independent reactions to bis-GA indicated specific exposure. Anaerobic sealants may induce sensitization not only to aliphatic (meth)acrylates but also to aromatic bis-GA.

• Authors: Kristiina Aalto-Korte, Soile Jungewelter, Maj-Len Henriks-Eckerman, Outi Kuuliala, Riitta Jolanki
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 61 Issue 1 Pg. 9-21 (Jul 2009) ISSN: 1600-0536 [Electronic] England
• PMID: 19659960 (Publication Type: Case Reports, Journal Article)

Chemical References

• 2,2-bis(4-(2-hydroxy-3-acryloxypropoxy)phenyl)propane
• Acrylates
• Benzhydryl Compounds
• Epoxy Compounds
• Epoxy Resins
• Methacrylates
• 2,2-bis-(4-(2-methacryloxyethoxy)phenyl)propane
• Bisphenol A-Glycidyl Methacrylate
• bisphenol A epoxy resin diacrylate ester
• glycidyl methacrylate

Topics

• Acrylates
• Adult
• Benzhydryl Compounds
• Bisphenol A-Glycidyl Methacrylate
• Dermatitis, Allergic Contact (epidemiology, etiology)
• Dermatitis, Occupational (epidemiology, etiology)
• Epoxy Compounds
• Epoxy Resins (adverse effects)
• Finland (epidemiology)
• Humans
• Male
• Methacrylates (adverse effects)
• Middle Aged
• Occupations
• Patch Tests
• Retrospective Studies