Acromegaly associated with multiple tumors.

Abstract

A 56-year-old man was admitted to our hospital for the surgical removal of renal cell carcinoma (RCC). He was diagnosed with acromegaly due to his characteristic clinical features, endocrine data, and the presence of pituitary tumor. He was found to have colon cancer and follicular thyroid tumor. Pathological examination of the pituitary tumor after transsphenoidal surgery was compatible with growth hormone (GH)-secreting pituitary adenoma. We also detected the transcripts and/or immunoreactivity of GH/insulin-like growth factor I components in the tumor specimen. This is a rare case of acromegaly associated with multiple tumors, including RCC, colon cancer and thyroid tumor.

• Authors: Naoko Sekizawa, Eri Hayakawa, Kyoichiro Tsuchiya, Takanobu Yoshimoto, Takumi Akashi, Takeshi Fujii, Shozo Yamada, Yukio Hirata
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 48 Issue 15 Pg. 1273-8 ( 2009) ISSN: 1349-7235 [Electronic] Japan
• PMID: 19652429 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA Primers
• Receptors, Somatotropin
• Insulin-Like Growth Factor I
• Receptor, IGF Type 1

Topics

• Acromegaly (etiology)
• Base Sequence
• Carcinoma, Renal Cell (complications, genetics, metabolism)
• Colonic Neoplasms (complications, genetics, metabolism)
• DNA Primers (genetics)
• Gene Expression
• Humans
• Immunohistochemistry
• Insulin-Like Growth Factor I (genetics, metabolism)
• Kidney Neoplasms (complications, genetics, metabolism)
• Male
• Middle Aged
• Neoplasms, Multiple Primary (complications, diagnosis, genetics, metabolism)
• Pituitary Neoplasms (complications, genetics, metabolism)
• Receptor, IGF Type 1 (genetics, metabolism)
• Receptors, Somatotropin (genetics, metabolism)
• Thyroid Neoplasms (complications, genetics, metabolism)