The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition.

Abstract

Circulating concentrations of insulin-like growth factor I (IGF-I) and IGF binding proteins (IGFBP) have been associated with the risk of several types of cancer. Dietary correlates of IGF-I and IGFBPs are not yet well established. The objective of this study was to assess the association between dietary intake and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in a cross-sectional analysis of 4,731 men and women taking part in the European Prospective Investigation into Cancer and Nutrition. Diet was assessed using country-specific validated dietary questionnaires. Serum concentrations of IGF-I, IGFBP-1, IGFBP-2 and IGFBP-3 were measured, and the associations between diet and IGF-I and IGFBPs were assessed using multiple linear regression adjusting for sex, age, body mass index, smoking status, and alcohol and energy intake. Each 1 SD increment increase in total and dairy protein and calcium intake was associated with an increase in IGF-I concentration of 2.5%, 2.4%, and 3.3%, respectively (P for trend <0.001 for all) and a decrease in IGFBP-2 of 3.5%, 3.5%, and 5.4% (P for trend <0.001 for all), respectively. There were no significant associations between the intake of protein or calcium from nondairy sources and IGF-I. The results from this large cross-sectional analysis show that either the intake of dairy protein or calcium is an important dietary determinant of IGF-I and IGFBP-2 concentrations; however, we suggest that it is more likely to be protein from dairy products.

• Authors: Francesca L Crowe, Timothy J Key, Naomi E Allen, Paul N Appleby, Andrew Roddam, Kim Overvad, Henning Grønbaek, Anne Tjønneland, Jutte Halkjaer, Laure Dossus, Heiner Boeing, Janine Kröger, Antonia Trichopoulou, Vardis Dilis, Dimitrios Trichopoulos, Marie-Christine Boutron-Ruault, Blandine De Lauzon, Françoise Clavel-Chapelon, Domenico Palli, Franco Berrino, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, H Bas Bueno-de-Mesquita, Alina Vrieling, Carla H van Gils, Petra H M Peeters, Inger T Gram, Guri Skeie, Eiliv Lund, Laudina Rodríguez, Paula Jakszyn, Esther Molina-Montes, María J Tormo, Aurelio Barricarte, Nerea Larrañaga, Kay-Tee Khaw, Sheila Bingham, Sabina Rinaldi, Nadia Slimani, Teresa Norat, Valentina Gallo, Elio Riboli, Rudolf Kaaks
• Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 18 Issue 5 Pg. 1333-40 (May 2009) ISSN: 1055-9965 [Print] United States
• PMID: 19423514 (Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Calcium, Dietary
• Insulin-Like Growth Factor Binding Protein 1
• Insulin-Like Growth Factor Binding Protein 2
• Insulin-Like Growth Factor Binding Protein 3
• Proteins
• Insulin-Like Growth Factor I

Topics

• Age Factors
• Body Mass Index
• Calcium, Dietary (administration & dosage)
• Cross-Sectional Studies
• Diet
• Energy Intake
• Europe
• Female
• Humans
• Insulin-Like Growth Factor Binding Protein 1 (blood)
• Insulin-Like Growth Factor Binding Protein 2 (blood)
• Insulin-Like Growth Factor Binding Protein 3 (blood)
• Insulin-Like Growth Factor I (metabolism)
• Linear Models
• Male
• Middle Aged
• Prospective Studies
• Proteins (administration & dosage)
• Sex Factors
• Surveys and Questionnaires