Inhibitory effect of methanol extract of Rosa damascena Mill. flowers on alpha-glucosidase activity and postprandial hyperglycemia in normal and diabetic rats.

Abstract

The effect of a methanol extract of Rosa damascena Mill. flowers was studied, in comparison to the alpha-glucosidase inhibitor acarbose, in normal and diabetic rats. The inhibition mode of this extract was examined by measuring enzyme activity in different concentrations of substrate for Lineweaver-Burk plot analysis. The results show that Rosa damascena extract has an intensive inhibitory effect on alpha-glucosidase. Its inhibition was found to be noncompetitive. Oral administration of this plant extract (100 to 1000 mg/kg body wt.) significantly decreased blood glucose after maltose loading in normal and diabetic rats in a dose-dependent manner. These results suggest that Rosa damascena might exert an anti-diabetic effect by suppressing carbohydrate absorption from the intestine and can reduce the postprandial glucose level.

• Authors: A Gholamhoseinian, H Fallah, F Sharifi far
• Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology (Phytomedicine) Vol. 16 Issue 10 Pg. 935-41 (Oct 2009) ISSN: 1618-095X [Electronic] Germany
• PMID: 19380218 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Glycoside Hydrolase Inhibitors
• Hypoglycemic Agents
• Plant Extracts
• Acarbose

Topics

• Acarbose (pharmacology)
• Animals
• Blood Glucose (drug effects)
• Diabetes Mellitus, Experimental (drug therapy)
• Glycoside Hydrolase Inhibitors
• Hypoglycemic Agents (analysis, pharmacology, therapeutic use)
• Kinetics
• Male
• Phytotherapy
• Plant Extracts (pharmacology, therapeutic use)
• Postprandial Period (drug effects)
• Rats
• Rats, Wistar
• Rosa (chemistry)