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Unilateral taxane-induced onychopathy in a patient with a brain metastasis.

Abstract
Chemotherapy using taxanes have been useful in the treatment of several types of solid tumors. Nail abnormalities have been reported primarily with the use of docetaxel, but also with low dose, weekly paclitaxel. We report a patient with 20-nail onycolysis associated with the use of paclitaxel that resolved after stopping the medication and then recurred after the use of docetaxel, but spared all the nails of a paretic hand.
AuthorsM Truchuelo, S Vano-Galvan, B Pérez, E Muñoz-Zato, P Jaén
JournalDermatology online journal (Dermatol Online J) Vol. 15 Issue 3 Pg. 7 (Mar 15 2009) ISSN: 1087-2108 [Electronic] United States
PMID19379651 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents, Phytogenic
  • Quinazolines
  • Taxoids
  • Lapatinib
  • Deoxycytidine
  • Docetaxel
  • Vinblastine
  • Capecitabine
  • Carboplatin
  • Trastuzumab
  • Paclitaxel
  • Vinorelbine
  • Fluorouracil
Topics
  • Antibodies, Monoclonal (administration & dosage)
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents, Phytogenic (administration & dosage, adverse effects)
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Brain Neoplasms (complications, drug therapy, secondary)
  • Breast Neoplasms (drug therapy, pathology, radiotherapy, surgery)
  • Capecitabine
  • Carboplatin (administration & dosage)
  • Combined Modality Therapy
  • Deoxycytidine (administration & dosage, analogs & derivatives)
  • Docetaxel
  • Fatal Outcome
  • Female
  • Fluorouracil (administration & dosage, analogs & derivatives)
  • Hand (innervation)
  • Humans
  • Lapatinib
  • Middle Aged
  • Onycholysis (chemically induced)
  • Paclitaxel (administration & dosage)
  • Paresis (etiology)
  • Peripheral Nervous System Diseases (chemically induced)
  • Quinazolines (administration & dosage)
  • Taxoids (administration & dosage, adverse effects)
  • Trastuzumab
  • Vinblastine (administration & dosage, analogs & derivatives)
  • Vinorelbine

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