[Treatment with indomethacin for the control of the metabolic disorder caused by a villous adenoma of the rectum].

Abstract

A 79 year old patient with a previous history of 10 months of mucous diarrhea is admitted due to pre-renal insufficiency, hyponatremia, hypokalemia and metabolic alkalosis secondary to rectal villous adenoma. The volume of the rectal discharge was 2.500 cc/day. Sodium level of the rectal secretion was 145 mEq/L and potassium 20 mEq/L. E2 prostaglandin: 1500 pg/ml. After hydroelectrolytic treatment, a PG synthetase inhibitor (indomethacin) was added to a dosage of 25 mg q/d PO. Rectal discharge was reduced to 500 cc/day, as well as sodium and prostaglandin levels. It has been proved that the use of PG synthetase inhibitors can facilitate the preparatory metabolic control in patients with villous adenoma.

• Authors: C Cutrin Prieto, L Casal Iglesias, A Batalla Eiras, M J Meniño Olveira, P Diéguez Gómez, V Lorenzo Zúniga
• Journal: Anales de medicina interna (Madrid, Spain : 1984) (An Med Interna) Vol. 8 Issue 7 Pg. 345-6 (Jul 1991) ISSN: 0212-7199 [Print] Spain
• Vernacular Title: Tratamiento con indometacina para el control del trastorno metabólico producido por un adenoma velloso de recto.
• PMID: 1932494 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Indomethacin

Topics

• Adenoma (complications)
• Aged
• Diarrhea (drug therapy, etiology)
• Female
• Humans
• Indomethacin (therapeutic use)
• Rectal Neoplasms (complications)
• Water-Electrolyte Imbalance (drug therapy, etiology)