Immunohistochemical and histopathological evaluation of 2,4-dichlorophenoxyacetic acid-induced changes in rat kidney cortex.

Abstract

This study aims to investigate the effect of 2,4-dichlorophenoxyacetic acid (2,4-D) on rat kidney cortex histology. Oral exposure of rats to 2,4-D for 28 days resulted in decreases in body weight gain and kidney weight. Histological examination showed degeneration in renal corpuscles and podocytes; vacuolization in the glomerulus with disintegration of the basal membrane; tissue edema; vacuolization, cystic dilation and invagination of the basal laminae in the tubular structures; dilation and congestion in renal corpuscular vessels and marked decrease in glomerular and stromal fibronectin reaction; suggesting that subacute 2,4-D administration induces dose-dependent histopathological degenerative effects in rat kidney cortex.

• Authors: Yiğit Uyanikgil, Utku Ateş, Meral Baka, Songül Biçer, Ebru Oztaş, Gürsel Ergen
• Journal: Bulletin of environmental contamination and toxicology (Bull Environ Contam Toxicol) Vol. 82 Issue 6 Pg. 749-55 (Jun 2009) ISSN: 1432-0800 [Electronic] United States
• PMID: 19277441 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Herbicides
• 2,4-Dichlorophenoxyacetic Acid

Topics

• 2,4-Dichlorophenoxyacetic Acid (toxicity)
• Animals
• Herbicides (toxicity)
• Immunohistochemistry
• Kidney Cortex (chemistry, drug effects, pathology)
• Male
• Rats
• Rats, Wistar
• Toxicity Tests, Chronic