Efficacy of piperacillin combined with the Penem beta-lactamase inhibitor BLI-489 in murine models of systemic infection.

Abstract

The in vivo efficacy of piperacillin in combination with the penem inhibitor BLI-489 was determined using acute lethal systemic infections in mice. On the basis of preliminary results with various ratios, a dosing ratio of 8:1 was found to be optimal for retention of enhanced efficacy. Piperacillin-BLI-489 dosed at an 8:1 ratio was efficacious against murine infections caused by class A (including extended-spectrum beta-lactamases), class C (AmpC), and class D beta-lactamase-expressing pathogens.

• Authors: Peter J Petersen, C Hal Jones, Aranapakam M Venkatesan, Patricia A Bradford
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 53 Issue 4 Pg. 1698-700 (Apr 2009) ISSN: 1098-6596 [Electronic] United States
• PMID: 19188386 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• BLI-489
• Lactams
• beta-Lactamase Inhibitors
• Piperacillin

Topics

• Animals
• Anti-Bacterial Agents (administration & dosage)
• Bacterial Infections (drug therapy)
• Disease Models, Animal
• Drug Therapy, Combination
• Female
• Lactams (administration & dosage)
• Mice
• Piperacillin (administration & dosage)
• beta-Lactamase Inhibitors