Abstract | BACKGROUND: Epithelial and mesenchymal transitions (EMT) are essential for embryonic development and progression of non-invasive tumor cells into malignant, metastatic carcinomas. During embryogenesis, the parathyroid glands develop from pharyngeal pouches and migrate to their final destinations, densely enclosed by mesenchymal neural crest cells. In this study, we examined the expression of the EMT markers Snail, Twist and E-cadherin in normal parathyroid glands and benign and malignant parathyroid diseases. METHODS: RESULTS: CONCLUSION: Expression of Snail and Twist at the invasive front and consecutive loss of E-cadherin in parathyroid carcinomas suggests a key role of EMT in the tumorigenesis of this cancer. The unique expression pattern could help to distinguish between an adenoma and a non-metastatic carcinoma. Loss of E-cadherin and change of the expression pattern of Snail and Twist together should result in an en bloc resection or a close follow-up.
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Authors | Volker Fendrich, Jens Waldmann, Georg Feldmann, Katja Schlosser, Alexander König, Annette Ramaswamy, Detlef K Bartsch, Elias Karakas |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 160
Issue 4
Pg. 695-703
(Apr 2009)
ISSN: 1479-683X [Electronic] England |
PMID | 19176646
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Cadherins
- Parathyroid Hormone
- Snail Family Transcription Factors
- Transcription Factors
- Twist-Related Protein 1
- Calcium
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
- Cadherins
(genetics, metabolism)
- Calcium
(blood)
- Cell Transformation, Neoplastic
(metabolism)
- Epithelial Cells
(physiology)
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Parathyroid Glands
(metabolism)
- Parathyroid Hormone
(blood)
- Parathyroid Neoplasms
(diagnosis, genetics, metabolism)
- Snail Family Transcription Factors
- Tissue Fixation
- Transcription Factors
(genetics, metabolism)
- Twist-Related Protein 1
(genetics, metabolism)
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