Comparison of glycemic variability associated with insulin glargine and intermediate-acting insulin when used as the basal component of multiple daily injections for adolescents with type 1 diabetes.

Abstract

OBJECTIVE:

To compare the glucose variability associated with insulin glargine and NPH/Lente insulin used as the basal insulin component of a multiple daily injection (MDI) regimen in pediatric patients with type 1 diabetes.

RESEARCH DESIGN AND METHODS:

Continuous glucose monitoring data were collected from a subset of patients (n = 90) who agreed to use a continuous glucose monitoring system during an active-controlled, randomized, open-label study evaluating the safety and efficacy of insulin glargine and NPH/Lente insulin used with insulin lispro as part of an MDI regimen.

RESULTS:

Treatment with insulin glargine resulted in significant reductions in glucose variability as measured by the SD of glucose values (adjusted mean change from baseline to week 24: -13.4 mg/dl [-0.74 mmol/l]; P <or= 0.05), mean amplitude of glycemic excursion (-34.4 mg/dl [-1.91 mmol/l]; P <or= 0.0001), and M value (-9.6 mg/dl [-0.53 mmol/l]; P <or= 0.03). The corresponding reductions in glucose variability for NPH/Lente were not significant.

CONCLUSIONS:

Insulin glargine is associated with greater reductions in glucose variability than NPH/Lente insulin in pediatric patients with type 1 diabetes.

• Authors: Neil H White, H Peter Chase, Silva Arslanian, William V Tamborlane, 4030 Study Group
• Journal: Diabetes care (Diabetes Care) Vol. 32 Issue 3 Pg. 387-93 (Mar 2009) ISSN: 1935-5548 [Electronic] United States
• PMID: 19106380 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Blood Glucose
• Hypoglycemic Agents
• Insulin
• Insulin, Long-Acting
• Insulin Glargine
• Insulin, Isophane

Topics

• Adolescent
• Blood Glucose (drug effects)
• Child
• Diabetes Mellitus, Type 1 (blood, drug therapy)
• Humans
• Hypoglycemic Agents (administration & dosage, pharmacology, therapeutic use)
• Injections (methods)
• Insulin (administration & dosage, analogs & derivatives, pharmacology, therapeutic use)
• Insulin Glargine
• Insulin, Isophane (administration & dosage, therapeutic use)
• Insulin, Long-Acting (administration & dosage, pharmacology, therapeutic use)