Abstract | PURPOSE OF REVIEW:
Nephrin, the main structural protein of the slit diaphragm, is expressed on the surface of glomerular podocytes and is critical in maintaining permselectivity and preventing proteinuria. This review focuses on the fate of nephrin in the context of endothelial injury and gives an update on the recent progress in understanding the pathomechanisms that lead to proteinuria. RECENT FINDINGS: SUMMARY: Recent results showed that damage to endothelial cells may alter endothelial-podocyte interaction and induces nephrin loss, a main cause of proteinuria.
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Authors | Peter V Hauser, Federica Collino, Benedetta Bussolati, Giovanni Camussi |
Journal | Current opinion in nephrology and hypertension
(Curr Opin Nephrol Hypertens)
Vol. 18
Issue 1
Pg. 3-8
(Jan 2009)
ISSN: 1473-6543 [Electronic] England |
PMID | 19077682
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Dietary Fats
- Membrane Proteins
- nephrin
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Topics |
- Animals
- Diabetic Nephropathies
(pathology)
- Dietary Fats
- Endothelial Cells
(pathology)
- Endothelium
(pathology)
- Female
- Humans
- Hypertension
(pathology)
- Kidney
(pathology)
- Kidney Glomerulus
(pathology)
- Membrane Proteins
(biosynthesis, chemistry, genetics, physiology)
- Podocytes
(pathology)
- Pre-Eclampsia
(metabolism, pathology)
- Pregnancy
- Signal Transduction
(physiology)
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