A new approach in specific, active immunotherapy.

Abstract

A vaccinia virus-lysed autochthonous tumor cell vaccine (vaccinia oncolysate) is introduced as a new specific, active immunotherapeutic agent against human cancer. Mouse experiments showed the vaccine to be a safe and potent immune mechanism stimulator. Human experimentation was undertaken in the knowledge of relative safety of the components of the vaccine, i.e. vaccinia vaccine and lysed, autochthonous tumor cells. Vaccine-treated patients had advanced metastatic cancer but reacted to one or more common recall antigen skin tests. None of the 13 patients had untoward responses; 7/13 patients had classic delayed hypersensitivity reactions at the vaccine injection sites; and 2/7 patients with injection site reactions had significant reduction in tumor burden. These results indicate that this vaccine is a specific, active immune mechanism stimulator, and may prove to be a useful therapeutic agent in the treatment of human cancer.

• Authors: M K Wallack, Z Steplewski, H Koprowski, E Rosato, J George, B Hulihan, J Johnson
• Journal: Cancer (Cancer) Vol. 39 Issue 2 Pg. 560-4 (Feb 1977) ISSN: 0008-543X [Print] United States
• PMID: 189895 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens, Neoplasm
• Antigens, Viral
• Histocompatibility Antigens

Topics

• Animals
• Antigens, Neoplasm
• Antigens, Viral
• Colonic Neoplasms (therapy)
• Female
• Histocompatibility Antigens
• Humans
• Immunotherapy (methods)
• Male
• Melanoma (therapy)
• Mice
• Mice, Inbred BALB C
• Middle Aged
• Neoplasms (immunology, therapy)
• Sarcoma, Experimental (immunology, therapy)
• Vaccinia virus (immunology)
• Viruses (immunology)