Abstract | BACKGROUND: METHODS: Different inhibitory and excitatory TMS parameters were investigated in 19 unmedicated female BPD patients and 19 healthy control subjects matched for sex, age, handedness, and body height. Additionally, the results were controlled for ADHD symptomatology. RESULTS: A reduced cortical silent period (CSP) duration was found in BPD patients compared with healthy control subjects in the right cortex. Even after controlling for ADHD symptoms, this result remained significant. CONCLUSIONS: These findings support an association between BPD and cortical inhibition deficits as indexed through TMS. The results are discussed considering basic neurobiological mechanisms that may explain our findings of decreased intracortical inhibition in BPD patients.
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Authors | Sven Barnow, Kathleen A Völker, Bertram Möller, Harald J Freyberger, Carsten Spitzer, Hans J Grabe, Zafiris J Daskalakis |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 65
Issue 4
Pg. 313-8
(Feb 15 2009)
ISSN: 1873-2402 [Electronic] United States |
PMID | 18823879
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Analysis of Variance
- Attention Deficit Disorder with Hyperactivity
(physiopathology, psychology)
- Borderline Personality Disorder
(physiopathology, psychology)
- Electroencephalography
- Female
- Functional Laterality
(physiology)
- Humans
- Psychiatric Status Rating Scales
- Transcranial Magnetic Stimulation
- Young Adult
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