Dynamic imaging of contrast enhancement in brain tumors.

Abstract

Gadolinium-DTPA has been shown to be a good probe for demonstrating defects in the blood-brain barrier, but it has a rapid rate of elimination so that peak circulating levels are short-lived. In this study ultrafast echo-planar imaging has been used in combination with a bolus injection of gadolinium-DTPA to evaluate perfusion within brain tumors and to assess the degree of disruption of the blood-brain barrier. The temporal profile of enhancement may allow discrimination between different tumor types.

• Authors: P R Bullock, P Mansfield, P Gowland, B S Worthington, J L Firth
• Journal: Magnetic resonance in medicine (Magn Reson Med) Vol. 19 Issue 2 Pg. 293-8 (Jun 1991) ISSN: 0740-3194 [Print] United States
• PMID: 1881318 (Publication Type: Journal Article)

Chemical References

• Contrast Media
• Organometallic Compounds
• Pentetic Acid
• Gadolinium
• Gadolinium DTPA

Topics

• Blood-Brain Barrier
• Brain (blood supply)
• Brain Neoplasms (blood supply, diagnosis)
• Contrast Media
• Gadolinium
• Gadolinium DTPA
• Humans
• Image Enhancement (methods)
• Magnetic Resonance Imaging (methods)
• Microcirculation
• Organometallic Compounds
• Pentetic Acid