Effect of pimobendan or benazepril hydrochloride on survival times in dogs with congestive heart failure caused by naturally occurring myxomatous mitral valve disease: the QUEST study.
Abstract | BACKGROUND: Myxomatous mitral valve disease (MMVD) continues to be an important cause of morbidity and mortality in geriatric dogs despite conventional therapy. HYPOTHESIS: ANIMALS: Two hundred and sixty client-owned dogs in CHF caused by MMVD were recruited from 28 centers in Europe, Canada, and Australia. METHODS: RESULTS: Eight dogs were excluded from analysis. One hundred and twenty-four dogs were randomized to pimobendan and 128 to benazepril. One hundred and ninety dogs reached the primary endpoint; the median time was 188 days (267 days for pimobendan, 140 days for benazepril hazard ratio = 0.688, 95% confidence limits [CL]=0.516-0.916, P= .0099). The benefit of pimobendan persisted after adjusting for all baseline variables. A longer time to reach the endpoint was also associated with being a Cavalier King Charles Spaniel, requiring a lower furosemide dose, and having a higher creatinine concentration. Increases in several indicators of cardiac enlargement (left atrial to aortic root ratio, vertebral heart scale, and percentage increase in left ventricular internal diameter in systole) were associated with a shorter time to endpoint, as was a worse tolerance for exercise. CONCLUSIONS AND CLINICAL IMPORTANCE:
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Authors | J Häggström, A Boswood, M O'Grady, O Jöns, S Smith, S Swift, M Borgarelli, B Gavaghan, J-G Kresken, M Patteson, B Ablad, C M Bussadori, T Glaus, A Kovacević, M Rapp, R A Santilli, A Tidholm, A Eriksson, M C Belanger, M Deinert, C J L Little, C Kvart, A French, M Rønn-Landbo, G Wess, A V Eggertsdottir, M L O'Sullivan, M Schneider, C W Lombard, J Dukes-McEwan, R Willis, A Louvet, R DiFruscia |
Journal | Journal of veterinary internal medicine
(J Vet Intern Med)
2008 Sep-Oct
Vol. 22
Issue 5
Pg. 1124-35
ISSN: 0891-6640 [Print] United States |
PMID | 18638016
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzazepines
- Cardiotonic Agents
- Pyridazines
- pimobendan
- benazepril
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Topics |
- Animals
- Benzazepines
(adverse effects, therapeutic use)
- Cardiotonic Agents
(adverse effects, therapeutic use)
- Dog Diseases
(drug therapy)
- Dogs
- Female
- Heart Failure
(complications, mortality, veterinary)
- Male
- Mitral Valve Insufficiency
(complications, drug therapy, veterinary)
- Multivariate Analysis
- Proportional Hazards Models
- Pyridazines
(adverse effects, therapeutic use)
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