Soluble RNA methylase activity of transplantable mouse hepatomas.

Abstract

The soluble ribonucleic acid (sRNA) methylase activity and the histology of several transplantable mouse hepatomas were examined. Three hepatomas (H-1, H-4, and H-6) were relatively fast growing. H-1 and H-6 hepatomas had higher sRNA methylase activity, H-4 had amounts of activity similar to those of liver, and H-3 hepatoma had variable amounts. sRNA methylase activity did not seem to be correlated with rate of growth but may have been associated with the state of differentiation.

• Authors: R L Hancock, J Grunau
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 45 Issue 5 Pg. 971-8 (Nov 1970) ISSN: 0027-8874 [Print] United States
• PMID: 18605423 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• tRNA Methyltransferases

Topics

• Animals
• Cell Differentiation
• Female
• Liver Neoplasms, Experimental (enzymology, pathology)
• Male
• Mice
• Mice, Inbred Strains
• Neoplasm Transplantation
• Solubility
• tRNA Methyltransferases (metabolism)