The differentiation-inducing effect of Nordy on HPV-16 subgenes-immortalized human endocervical cells H8.

Abstract	The lipoxygenase inhibitor nordihydroguaiaretic acid, a natural product purified from Larrea divaricata and Guaiacum officinale, showed a marked capacity to induce differentiation of various human malignant tumor cell lines. Nordy, a derivative of nordihydroguaiaretic acid, has been shown to effectively inhibit the growth of malignant human tumors transplanted in mice. However, it is unknown whether Nordy plays an important role in inducing the differentiation effects of human papillomavirus (HPV)-16 subgenes-immortalized human endocervical cells H8. In this study, we showed that Nordy arrested H8 cells in the G0/G1 phase, promoted cell differentiation in morphology, downregulated the expression of HPV-16 E6 mRNA and nuclear antigen Ki67, and inhibited telomerase activity on HPV-16 subgenes-immortalized human endocervical cells H8. Taken together, Nordy could suppress proliferation by inhibiting proliferation-related events and promote cell differentiation in H8 cell. The results suggested that Nordy might be a potential tumor therapeutic agent.
Authors	Jing Zhao, Yong Zhao, Wei Chen, Yi-Min Li, Xiu-Wu Bian
Journal	Anti-cancer drugs (Anticancer Drugs) Vol. 19 Issue 7 Pg. 713-9 (Aug 2008) ISSN: 0959-4973 [Print] England
PMID	18594213 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	E6 protein, Human papillomavirus type 16 Ki-67 Antigen Lipoxygenase Inhibitors Oncogene Proteins, Viral RNA, Messenger Repressor Proteins nordy Masoprocol Telomerase
Topics	Cell Cycle (drug effects) Cell Differentiation (drug effects) Cell Line Cell Proliferation (drug effects) Cervix Uteri (cytology, virology) Female Human papillomavirus 16 (genetics) Humans Ki-67 Antigen (analysis) Lipoxygenase Inhibitors (pharmacology) Masoprocol (analogs & derivatives, pharmacology) Oncogene Proteins, Viral (genetics) RNA, Messenger (analysis) Repressor Proteins (genetics) Telomerase (metabolism)

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