Abstract |
Guillain-Barré syndrome is divided into two subtypes: acute inflammatory demyelinating polyneuropathy, and acute motor axonal neuropathy. Autoantibodies to gangliosides GM1, GM1b, GD1a, or GalNAc-GD1a were proposed as serologic markers of acute motor axonal neuropathy in adults. In a previous study of Japanese children with Guillain-Barré syndrome, acute motor axonal neuropathy was associated with anti-GM1 immunoglobulin G antibodies. Larger, comprehensive studies are required to confirm this finding. The present study revealed that immunoglobulin G antibodies were against GM1 (34%), GM1b (22%), GD1a (25%), GalNAc-GD1a (13%), and any of these (44%) in 32 Japanese children with Guillain-Barré syndrome. Patients who had the autoantibodies more often manifested previous diarrhea (71% vs 11%, P = 0.001), acute motor axonal neuropathy (64% vs 11%, P = 0.003), and slower recovery (healthy at final follow-up: 29% vs 78%, P = 0.011; able to run with minor signs, 64% vs 11%, P = 0.003) than patients who did not. The clinical features were consistent with those in adults carrying anti- ganglioside antibodies. Anti- ganglioside antibody testing may help predict outcomes in pediatric patients with Guillain-Barré syndrome who prefer not to undergo repeated nerve-conduction studies.
|
Authors | Yukihiro Nishimoto, Keiichiro Susuki, Nobuhiro Yuki |
Journal | Pediatric neurology
(Pediatr Neurol)
Vol. 39
Issue 1
Pg. 67-70
(Jul 2008)
ISSN: 0887-8994 [Print] United States |
PMID | 18555178
(Publication Type: Journal Article)
|
Chemical References |
- Autoantibodies
- Biomarkers
- Gangliosides
- Immunoglobulins
|
Topics |
- Adolescent
- Autoantibodies
(blood)
- Axons
(pathology)
- Biomarkers
(blood)
- Campylobacter Infections
(immunology)
- Campylobacter jejuni
(immunology)
- Child
- Child, Preschool
- Electrodiagnosis
- Electroencephalography
- Female
- Gangliosides
(immunology)
- Guillain-Barre Syndrome
(blood, pathology)
- Humans
- Immunoglobulins
(blood)
- Infant
- Male
- Prognosis
|