The roles of sPLA2-IIA (Pla2g2a) in cancer of the small and large intestine.

Abstract

The mouse secretory phospholipase A2 group IIA (sPLA2-IIA) gene Pla2g2a has been identified as a susceptibility gene for cancer of the small and large intestine. Interestingly, unlike most previously identified tumor susceptibility genes, Pla2g2a does not behave like a classical oncogene or tumor suppressor gene. Hence, identification of its biological functions in tumor development may shed new light on general mechanisms that modulate colon cancer risk. So far, sPLA2-IIA has been proposed to play a role in anti-bacterial defense, inflammation and eicosanoid generation, in clearance of apoptotic cells, and in the Wnt signaling pathway. More recently, comparison of RNA expression profiles of colon from Pla2g2a-transgenic to Pla2g2a-deficient mice confirmed and even extended sPLA2-IIA's diverse biological effects. In this review we aim to summarize current knowledge about the various links of sPLA2-IIA to cancer of the gastro-intestinal tract, and propose several models to illustrate its putative biological effects on tumor development.

• Authors: Remond J A Fijneman, Robert T Cormier
• Journal: Frontiers in bioscience : a journal and virtual library (Front Biosci) Vol. 13 Pg. 4144-74 (May 01 2008) ISSN: 1093-9946 [Print] United States
• PMID: 18508504 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Receptors, Notch
• Wnt Proteins
• Group II Phospholipases A2
• PLA2G2A protein, human
• Pla2g2a protein, mouse

Topics

• Animals
• Apoptosis
• Colonic Neoplasms (enzymology, genetics, pathology, physiopathology)
• Genetic Predisposition to Disease
• Group II Phospholipases A2 (genetics, metabolism)
• Homeostasis
• Humans
• Inflammation (genetics, physiopathology)
• Intestinal Neoplasms (enzymology, genetics, pathology, physiopathology)
• Mice
• Receptors, Notch (physiology)
• Signal Transduction
• Wnt Proteins (physiology)