Abstract | BACKGROUND: AIM OF THE WORK: METHODS: 14 patients with chronic summer-type HP diagnosed between 2000 and 2005 were reviewed retrospectively. RESULTS: KL-6, a mucin-like glycoprotein, and surfactant protein-D ( SP-D) were elevated in most cases. Specific antibodies against Trichosporon asahii (T. asahii) and T. mucoides in sera and BAL fluids were positive in 12 of 14 cases. A lymphocyte proliferation test induced by Trichosporon related antigen was positive in all examined cases (n=5). On high-resolution CT, traction bronchiectasis and honeycombing were observed in more than 70% of cases. By video-assisted thoracoscopic surgery (VATS) and autopsy specimens, honeycombing, fibroblastic foci, centrilobular fibrosis, and bridging fibrosis between bronchiolar and subpleural areas were observed. Antigen avoidance by improving domestic environments kept patients stable without decline in vital capacity (VC). However, 3 of the 4 patients who did not remedy their houses died of respiratory failure after progression of this disease. CONCLUSION: Correct diagnosis in the early stage is crucial, since chronic summer-type HP can result in a fatal outcome after continuous exposure to the causative antigen.
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Authors | Naohiko Inase, Yoshio Ohtani, Yutaka Usui, Yasunari Miyazaki, Tamiko Takemura, Yasuyuki Yoshizawa |
Journal | Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG
(Sarcoidosis Vasc Diffuse Lung Dis)
Vol. 24
Issue 2
Pg. 141-7
(Sep 2007)
ISSN: 1124-0490 [Print] Italy |
PMID | 18496985
(Publication Type: Journal Article)
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Topics |
- Aged
- Alveolitis, Extrinsic Allergic
(complications, diagnosis, immunology)
- Bronchoalveolar Lavage
- Chronic Disease
- Disease Progression
- Female
- Humans
- Male
- Middle Aged
- Pulmonary Fibrosis
(immunology)
- Retrospective Studies
- Seasons
- Thoracic Surgery, Video-Assisted
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