Synthesis of methylenecyclobutyl- and cyclobutenyl adenine A, potent antiviral carbocyclic analogues of oxetanocin A.

Abstract

9-Cyclobutyladenines bearing both methylene and hydroxymethyl groups, 3 and 4, were prepared by dehydration of carbocyclic oxetanocin A, 1a. Introduction of a double bond into cyclobutane ring was achieved by allylic oxidation of 12, which after several steps, afforded 5.

• Authors: T Maruyama, Y Hanai, Y Sato
• Journal: Nucleic acids symposium series (Nucleic Acids Symp Ser) Issue 25 Pg. 87-8 ( 1991) ISSN: 0261-3166 [Print] England
• PMID: 1842109 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• oxetanocin
• angustmycin A
• neplanocin A
• Adenine
• Adenosine

Topics

• Adenine (analogs & derivatives, chemistry)
• Adenosine (analogs & derivatives, chemistry)
• Antiviral Agents (chemistry)
• Molecular Structure