Severe labetalol overdose in an 8-month-old infant.

Abstract	We report a case of a large labetalol overdose in an eight-month-old infant that was being treated for hypertension following surgery for coarctation of the aorta. Labetalol, both alpha and beta adrenergic blocking agent was used for treating postoperative hypertension. By mistake, the patient was given an extremely high dose of labetalol intravenously (17.2 mg.kg(-1)). Remarkably, the medication error had a surprisingly limited clinical effect on the infant who survived the incident. We discuss the pharmacokinetic, pharmocodynamic and possible explanations for this fortunate turn of events.
Authors	Adalbjörn Thorsteinsson, Astridur Johannesdottir, Herbert Eiríksson, Hródmar Helgason
Journal	Paediatric anaesthesia (Paediatr Anaesth) Vol. 18 Issue 5 Pg. 435-8 (May 2008) ISSN: 1460-9592 [Electronic] France
PMID	18312512 (Publication Type: Case Reports, Journal Article)
Chemical References	Antihypertensive Agents Labetalol
Topics	Antihypertensive Agents (administration & dosage, therapeutic use) Aortic Coarctation (surgery) Female Humans Hypertension (drug therapy) Infant Labetalol (administration & dosage, therapeutic use) Medication Errors Postoperative Complications (drug therapy)

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