Regulation of purine metabolism. Adenylosuccinate synthetase from Novikoff ascites tumor cells.

Abstract	Adenylosuccinate synthetase has been partially purified from Novikoff ascites tumor cells. The properties of the protein are quite different from the enzyme from rat liver in that the Km for asparate is higher and the K1 for the feedback inhibitor AMP is also higher. The antibiotic hadacidin has a preferential inhibitory effect on the tumor enzyme. These results suggest that the Novikoff ascites tumor enzyme is less sensitive to normal feedback controls but may be more sensitive to specific antitumor drugs.
Authors	A W Clark, F B Rudolph
Journal	Biochimica et biophysica acta (Biochim Biophys Acta) Vol. 437 Issue 1 Pg. 87-90 (Jun 23 1976) ISSN: 0006-3002 [Print] Netherlands
PMID	181081 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Anti-Bacterial Agents Inosine Nucleotides Aspartic Acid Adenosine Monophosphate Guanosine Triphosphate Ligases
Topics	Adenosine Monophosphate (pharmacology) Animals Anti-Bacterial Agents (pharmacology) Aspartic Acid (pharmacology) Carcinoma, Hepatocellular (enzymology) Feedback Guanosine Triphosphate (pharmacology) Inosine Nucleotides (pharmacology) Kinetics Ligases (isolation & purification, metabolism) Liver Neoplasms Neoplasms, Experimental (enzymology) Rats

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