Interruptions of tenofovir/emtricitabine-based antiretroviral therapy in patients with HIV/hepatitis B virus co-infection.

Abstract

Thai patients enrolled in STACCATO with HIV/hepatitis B virus (HBV) co-infection and tenofovir/emtricitabine-based antiretroviral therapy (ART) were randomly assigned to continuous treatment or CD4 cell count-guided interruptions. HBV replication was suppressed below detection in 15/16 patients. Structured treatment interruption increased transaminases and HBV viraemia in five of six patients; one flare was severe. Conversion to anti-hepatitis Be occurred with continuous treatment only. Tenofovir/emtricitabine-containing ART is highly effective in controlling chronic HIV/HBV co-infection but treatment should not be interrupted.

• Authors: Reto Nüesch, Jintanat Ananworanich, Preeyaporn Srasuebkul, Ploenchan Chetchotisakd, Wisit Prasithsirikul, Wirat Klinbuayam, Apicha Mahanontharit, Thidarat Jupimai, Kiat Ruxrungtham, Bernard Hirschel
• Journal: AIDS (London, England) (AIDS) Vol. 22 Issue 1 Pg. 152-4 (Jan 02 2008) ISSN: 1473-5571 [Electronic] England
• PMID: 18090405 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Retroviral Agents
• Antiviral Agents
• Hepatitis B e Antigens
• Organophosphonates
• Deoxycytidine
• Tenofovir
• Transaminases
• Emtricitabine
• Adenine

Topics

• Adenine (administration & dosage, analogs & derivatives)
• Anti-Retroviral Agents (administration & dosage)
• Antiretroviral Therapy, Highly Active
• Antiviral Agents (administration & dosage)
• Deoxycytidine (administration & dosage, analogs & derivatives)
• Drug Administration Schedule
• Emtricitabine
• Female
• HIV
• HIV Infections (complications, drug therapy)
• Hepatitis B e Antigens (blood)
• Hepatitis B virus (immunology, isolation & purification)
• Hepatitis B, Chronic (blood, complications, drug therapy, virology)
• Humans
• Male
• Organophosphonates (administration & dosage)
• Tenofovir
• Thailand
• Transaminases (blood)
• Treatment Outcome
• Viral Load