Functional analysis of CD8+ T cell responses to the onconeural self protein cdr2 in patients with paraneoplastic cerebellar degeneration.

Abstract

Paraneoplastic cerebellar degeneration (PCD) is linked to an immune response against cerebellar degeneration related antigen 2 (cdr2) co-expressed in tumor and Purkinje neurons. Here, comprehensive immune-assessment assays were used to analyze CD8(+) T cells from 7 PCD patients, but no evidence was found of CD8(+) T cells specific for either of two previously described cdr2 epitopes (cdr2-1 and cdr2-2). In contrast, viral-specific CD8(+) T cells from healthy volunteers and PCD patients were measurable. These findings are inconsistent with an obligate role for cdr2-1- or cdr2-2-specific CD8(+) T cells in the pathogenesis of PCD.

• Authors: Erica L Carpenter, Barbara A Vance, Rachel S Klein, Alfredo Voloschin, Josep Dalmau, Robert H Vonderheide
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 193 Issue 1-2 Pg. 173-82 (Jan 2008) ISSN: 0165-5728 [Print] Netherlands
• PMID: 18053582 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CDR2 protein, human
• HLA-A2 Antigen
• Lysosomal-Associated Membrane Protein 1
• Nerve Tissue Proteins
• Tumor Necrosis Factor-alpha
• Interferon-gamma

Topics

• Adult
• Aged
• CD8-Positive T-Lymphocytes (immunology)
• Female
• HLA-A2 Antigen (metabolism)
• Humans
• Interferon-gamma (biosynthesis)
• Lymphocyte Activation
• Lysosomal-Associated Membrane Protein 1 (analysis)
• Middle Aged
• Nerve Tissue Proteins (immunology, metabolism)
• Paraneoplastic Cerebellar Degeneration (etiology, immunology)
• Tumor Necrosis Factor-alpha (biosynthesis)