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Controlling recurrent papillary thyroid carcinoma in the neck by ultrasonography-guided percutaneous ethanol injection.

Abstract
The purpose of this study was to retrospectively evaluate the efficacy of ultrasonography-guided percutaneous ethanol injection (PEI) for neck recurrence of papillary thyroid carcinoma (NR-PTC). Twenty-seven patients (19-80 years old; mean, 53.2) with 47 NR-PTCs were treated by PEI and were followed-up (14-38 months; mean, 28.2). Ethanol (99%) was repeatedly injected with adjusting needle position until the entire volume of NR-PTC was ablated. All patients received follow-up ultrasonography at 3-6-month intervals, and the percent volume decrease was measured. The NR-PTCs with decreased volume and no tumor vascularity on power-Doppler study were regarded as treatment-effective. The NR-PTCs with stable or enlarged volume or with tumor vascularity were considered as treatment-failed, in which case PEI was repeated. The number of sessions and the total volume of ethanol per NR-PTC, and the volume of ethanol per session per NR-PTC were evaluated. All NR-PTCs significantly decreased in volume (range, 30-100%; mean, 93.6%). The mean number of sessions, the total volume of ethanol per NR-PTC, and the mean volume of ethanol per session per NR-PTC were 2.1 sessions (range 1-6), 2.4 ml (range 0.3-10.1), and 1.1 ml/session (range 0.3-3.0), respectively. PEI appears to be an alternative option for controlling NR-PTCs in the selected patients who are poor surgical candidates.
AuthorsByung Moon Kim, Min Jung Kim, Eun-Kyung Kim, Sung Il Park, Cheong Soo Park, Woong Youn Chung
JournalEuropean radiology (Eur Radiol) Vol. 18 Issue 4 Pg. 835-42 (Apr 2008) ISSN: 0938-7994 [Print] Germany
PMID18040692 (Publication Type: Journal Article)
Chemical References
  • Ethanol
Topics
  • Adenocarcinoma, Papillary (diagnostic imaging, drug therapy)
  • Adult
  • Aged
  • Aged, 80 and over
  • Ethanol (administration & dosage)
  • Female
  • Follow-Up Studies
  • Humans
  • Injections, Intralesional
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local (diagnostic imaging, prevention & control)
  • Retrospective Studies
  • Thyroid Neoplasms (diagnostic imaging, drug therapy)
  • Treatment Outcome
  • Ultrasonography, Interventional

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