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Role of partial hepatectomy on Capillaria hepatica-induced hepatic fibrosis in rats.

Abstract
It is known that hepatic fibrosis may regress following partial hepatectomy, since the hepatic parenchyma regenerates very rapidly, but not the excess of fibrous tissue. The present study evaluated this hypothesis by observing the behavior of systematized septal fibrosis induced by either 30 or 90-day-old Capillaria hepatica infection, in rats subjected to partial hepatectomy. The results revealed that the morphology of the fibrosis was unaffected, but its relative quantity within the microscope field appeared significantly decreased, as a consequence of the increased liver tissue mass following regeneration.
AuthorsCarolina Cincurá Silva Santos, Záira Onofre-Nunes, Zilton Araujo Andrade
JournalRevista da Sociedade Brasileira de Medicina Tropical (Rev Soc Bras Med Trop) 2007 Sep-Oct Vol. 40 Issue 5 Pg. 495-8 ISSN: 0037-8682 [Print] Brazil
PMID17992401 (Publication Type: Journal Article)
Topics
  • Animals
  • Capillaria
  • Enoplida Infections (complications, pathology)
  • Female
  • Hepatectomy
  • Liver Cirrhosis, Experimental (parasitology, pathology, surgery)
  • Liver Diseases, Parasitic (parasitology, pathology, surgery)
  • Liver Regeneration
  • Male
  • Rats
  • Time Factors

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