TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study.

Abstract

BACKGROUND:

Transforming growth factor beta 1 (TGFB1) forms a signaling complex with transforming growth factor beta receptors 1 and 2 and has been described as both a tumor suppressor and tumor promoter. Single nucleotide polymorphisms in TGFB1 and a microsatellite in TGFBR1 have been investigated for association with risk of breast cancer, with conflicting results.

METHODS:

We examined polymorphisms in the promoter region of the TGFB1 gene as well as the TGFBR1*6A microsatellite in the Nurses' Health Study cohort.

RESULTS:

No overall associations between the L10P polymorphism of TGFB1 or the TGFBR1 microsatellite were detected. However, we observed an inverse association between the -509 C/T polymorphism of TGFB1 (p-trend = 0.04), which was stronger and more significant among women with estrogen receptor positive breast cancer.

CONCLUSION:

Polymorphisms in the promoter region of TGFB1 are not likely to be associated with large increases in breast cancer risk overall among Caucasian women.

• Authors: David G Cox, Kathryn Penney, Qun Guo, Susan E Hankinson, David J Hunter
• Journal: BMC cancer (BMC Cancer) Vol. 7 Pg. 175 (Sep 11 2007) ISSN: 1471-2407 [Electronic] England
• PMID: 17848193 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Receptors, Transforming Growth Factor beta
• TGFB1 protein, human
• Transforming Growth Factor beta1
• Protein Serine-Threonine Kinases
• Receptor, Transforming Growth Factor-beta Type I
• TGFBR1 protein, human

Topics

• Adult
• Breast Neoplasms (genetics)
• Female
• Humans
• Microsatellite Repeats
• Middle Aged
• Polymorphism, Single Nucleotide
• Promoter Regions, Genetic
• Protein Serine-Threonine Kinases (genetics)
• Receptor, Transforming Growth Factor-beta Type I
• Receptors, Transforming Growth Factor beta (genetics)
• Risk
• Transforming Growth Factor beta1 (genetics)