Abstract | BACKGROUND: METHODS: RESULTS: A total of 3049 patients with multiple myeloma (n = 513), breast (n = 1130), prostate (n = 640), or lung cancer or other solid tumors (n = 766) were included in this analysis. Patients with multiple myeloma had the highest fracture incidence (43%), followed by breast (35%), prostate (19%), and lung cancer (17%). In all tumor types except lung, pathologic fracture was associated with a significant increase in risk of death, and breast cancer patients had the greatest increased risk. After adjustment for baseline characteristics, including performance status and prior skeletal complications, breast cancer patients who developed a pathologic fracture on study had a significant 32% increased risk of death relative to patients without a fracture (hazard ratio = 1.32; P < .01); patients with multiple myeloma or prostate cancer had a >20% increased risk of death. CONCLUSIONS: These results suggest that fractures are associated with increased risk of death in patients with malignant bone disease. Therefore, preventing fractures is an important goal of therapy.
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Authors | Fred Saad, Allan Lipton, Richard Cook, Yin-Miao Chen, Matthew Smith, Robert Coleman |
Journal | Cancer
(Cancer)
Vol. 110
Issue 8
Pg. 1860-7
(Oct 15 2007)
ISSN: 0008-543X [Print] United States |
PMID | 17763372
(Publication Type: Clinical Trial, Phase III, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Double-Blind Method
- Female
- Fractures, Bone
(mortality)
- Humans
- Male
- Middle Aged
- Neoplasms
(mortality)
- Retrospective Studies
- Risk Factors
- Survival Rate
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