Prophylactic platelet transfusion in children with thrombocytopenic disorders: a retrospective review.

Abstract

The safety of low platelet thresholds for prophylactic transfusions was retrospectively evaluated in 673 children with various thrombocytopenic disorders. In patients with idiopathic thrombocytopenic purpura and X linked thrombocytopenia the threshold for the use of platelet transfusion was based on bleeding events rather than platelet count. In children with hypoproliferative thrombocytopenia and Wiskott-Aldrich syndrome, prophylactic platelet transfusions were used when the platelet count was <or= 5000/microl in stable patients and > 10,000/microl in cases of bleeding or infections. The restrictive policy of platelet transfusions was shown to be proved safe in many thrombocytopenic disorders.

• Authors: M Ferrara, L Capozzi, A Coppola, G Save, L Coppola
• Journal: Hematology (Amsterdam, Netherlands) (Hematology) Vol. 12 Issue 4 Pg. 297-9 (Aug 2007) ISSN: 1607-8454 [Electronic] England
• PMID: 17654055 (Publication Type: Evaluation Study, Journal Article)

Topics

• Adolescent
• Adult
• Anemia, Aplastic (complications, therapy)
• Child
• Child, Preschool
• Fanconi Anemia (complications, therapy)
• Female
• Follow-Up Studies
• Genetic Diseases, X-Linked (complications, therapy)
• Hemorrhage (etiology)
• Humans
• Male
• Platelet Count (statistics & numerical data)
• Platelet Transfusion (adverse effects, statistics & numerical data)
• Purpura, Thrombocytopenic, Idiopathic (therapy)
• Retrospective Studies
• Severity of Illness Index
• Thrombocytopenia (etiology, genetics, therapy)
• Wiskott-Aldrich Syndrome (complications, therapy)