Abstract |
The in vivo efficacy of the novel polymeric guanidine AKACID Plus was evaluated in a guinea pig model of experimental skin infection with methicillin-resistant Staphylococcus aureus (MRSA). Topical application of AKACID Plus at concentrations of > or =0.5% was as effective as mupirocin 2% cream in the treatment of superficial skin infection with MRSA.
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Authors | Christina Kratzer, Selma Tobudic, Karin Macfelda, Wolfgang Graninger, Apostolos Georgopoulos |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 51
Issue 9
Pg. 3437-9
(Sep 2007)
ISSN: 0066-4804 [Print] United States |
PMID | 17620381
(Publication Type: Journal Article)
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Chemical References |
- AKACID Plus
- Anti-Bacterial Agents
- Guanidines
- Polymers
- Mupirocin
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Topics |
- Animals
- Anti-Bacterial Agents
(therapeutic use)
- Colony Count, Microbial
- Dose-Response Relationship, Drug
- Female
- Guanidines
(therapeutic use)
- Guinea Pigs
- Male
- Methicillin Resistance
- Mupirocin
(pharmacology)
- Polymers
(therapeutic use)
- Skin
(microbiology)
- Skin Diseases, Infectious
(drug therapy)
- Staphylococcal Infections
(drug therapy, microbiology)
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