Intralesional injection of OK-432 for vision-threatening orbital lymphangioma.

Abstract

BACKGROUND:

Surgical excision of orbital lymphangiomas is difficult, and almost always incomplete due to the diffusely infiltrative pattern of these tumors. The present report describes the successful use of intralesional OK-432 administration to treat two patients with intractable hemorrhagic proptosis due to orbital lymphangiomas.

METHODS:

A 3-year-old girl (case 1) presented with aggressive proptosis and ptosis, and a 1-year-old boy (case 2) presented with massive proptosis and exposure keratopathy, associated with recurrent intracystic bleeding of an orbital lymphangioma. In case 1, 0.02 mg OK-432 was intracystically injected in a volume of 2 ml of physiologic saline. Due to a lack of therapeutic response, a second injection of 0.05 mg OK-432 in 1 ml was administered. In case 2, a single dose of 0.05 mg OK-432 in 1 ml was administered.

RESULTS:

In both cases, intracystic administration of 0.05 mg of OK-432 in a 1-ml volume resulted in a successful outcome. The adverse effects were minor (mild transient fever and lid swelling), and rebleeding and intraocular pressure elevation did not occur. Proptosis and eyelid swelling gradually improved over 1 month, and completely resolved within 3 months of treatment.

CONCLUSIONS:

Intralesional administration of 0.05 mg/ml OK-432 (delivered in 1 ml) resulted in the successful treatment of two cases of orbital lymphangioma. Although this drug concentration is higher than in previous reports, there were no major adverse effects.

• Authors: Jin Sook Yoon, Jung Bum Choi, Sung Joo Kim, Sang Yeul Lee
• Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (Graefes Arch Clin Exp Ophthalmol) Vol. 245 Issue 7 Pg. 1031-5 (Jul 2007) ISSN: 0721-832X [Print] Germany
• PMID: 17577592 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Picibanil

Topics

• Antineoplastic Agents (administration & dosage)
• Child, Preschool
• Female
• Humans
• Infant
• Injections, Intralesional
• Lymphangioma (drug therapy, pathology)
• Magnetic Resonance Imaging
• Male
• Orbital Neoplasms (drug therapy, pathology)
• Picibanil (administration & dosage)
• Retreatment
• Tomography, X-Ray Computed